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TNFSF15 Rekombinanter Antikörper

TNFSF15 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

251018A11

Kat-Nr. : 83700-3-PBS

Synonyme

TNFSF 15, Tumor necrosis factor ligand superfamily member 15, Tumor necrosis factor ligand superfamily member 15, membrane form, Tumor necrosis factor ligand superfamily member 15, secreted form

Filter:
  • Western Blot (WB) analysis of various lysates using TNFSF15 Recombinant antibody (83700-3-RR)

    WB analysis using 83700-3-RR (same clone as 83700-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83700-3-RR (TNFSF15 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83700-3-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83700-3-RR

    Affinity and Kinetic Characterization of 83700-3-RR

    Biolayer interferometry (BLl) kinetic assays of 83700-3-RR against Human TNFSF15 were performed. The affinity constant is 0.291 nM.

Geprüfte Anwendungen

Produktinformation

83700-3-PBS bindet in WB, Indirect ELISA TNFSF15 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen TNFSF15 fusion protein Eg32092
Vollständiger Name tumor necrosis factor (ligand) superfamily, member 15
Berechnetes Molekulargewicht 28 kDa
Beobachtetes Molekulargewicht28 kDa
GenBank-ZugangsnummerBC074941
Gene symbol TNFSF15
Gene ID (NCBI) 9966
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Tumor necrosis factor ligand superfamily member 15 (TNFSF15) is also named as TL1 and VEGI. And it belongs to the tumor necrosis factor family. It is a receptor for TNFRSF25 and TNFRSF6B. VEGI induced degradation of IκB alpha, and nuclear translocation of p65 subunit of NFκB by activating NFκB (PMID: 10597252). TL1A mediates activation and apoptosis of NFκB in DR3-expressing cell lines (PMID: 11911831). Overexpression by cancer cells of a secretable VEGI fusion protein resulted in abrogation of xenograft tumor progression. The isoforms show endothelial cell-specific expression and are generated from a 17 kb human gene by alternative splicing (PMID: 11923219). In addition, VEGI can inhibit vascular endothelial growth and angiogenesis (in vitro) (PMID: 9872942).