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TNIK Polyklonaler Antikörper

TNIK Polyklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 30906-1-PBS

Synonyme

EC:2.7.11.1, KIAA0551, TRAF2 and NCK-interacting protein kinase

Filter:
  • Western Blot (WB) analysis of various lysates using TNIK Polyclonal antibody (30906-1-AP)

    WB analysis using 30906-1-AP (same clone as 30906-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30906-1-AP (TNIK antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30906-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using TNIK Polyclonal antibody (30906-1-AP)

    WB analysis using 30906-1-AP (same clone as 30906-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30906-1-AP (TNIK antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30906-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of K-562 cells using TNIK Polyclonal antibody (30906-1-AP)

    IF Staining of K-562 using 30906-1-AP (same clone as 30906-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed K-562 cells using TNIK antibody (30906-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 30906-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

30906-1-PBS bindet in WB, IF/ICC, Indirect ELISA TNIK und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TNIK fusion protein Ag34132
Vollständiger Name TRAF2 and NCK interacting kinase
Beobachtetes Molekulargewicht155~180 kDa
GenBank-ZugangsnummerBC150256
Gene symbol TNIK
Gene ID (NCBI) 23043
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TNIK (Traf2- and Nck-interacting kinase) is one of the germinal center kinase family members involved in cytoskeleton organization and neuronal dendrite extension, which had been implicated in postsynaptic signaling as well as in regulation of cell proliferation. TNiK is expressed in the nervous system and plays key roles at the synapse and nucleus, In non-neuronal cells, TNiK has been described as a critical component of transcriptional regulatory mechanisms, mediated by Wnt signaling (PMID: 24566388). TNIK is also an essential regulatory component of the T-cell factor-4 and β-catenin transcriptional complex and is required for the tumor-initiating function of colorectal cancer stem cells (PMID: 10521462). Western blot analysis detected TNIK at an apparent molecular mass of 150~180 kDa as cited in literature (PMID: 24566388).