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TNN Polyklonaler Antikörper

TNN Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 24839-1-PBS

Synonyme

tenascin N, TN W, TN N, tenascin-N

Filter:
  • Western Blot (WB) analysis of various lysates using TNN Polyclonal antibody (24839-1-AP)

    WB analysis using 24839-1-AP (same clone as 24839-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 24839-1-AP (TNN antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24839-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

24839-1-PBS bindet in WB, Indirect ELISA TNN und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TNN fusion protein Ag18127
Vollständiger Name tenascin N
Berechnetes Molekulargewicht 1299 aa, 144 kDa
Beobachtetes Molekulargewicht144 kDa, 173 kDa
GenBank-ZugangsnummerBC136619
Gene symbol TNN
Gene ID (NCBI) 63923
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TNN (Tenascin-W), also known as TNW. It is expected to be located in the extracellular space. The protein is not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PMID:17909022). And in brain tumors, detected around the endothelial cell layer of the clood vessels (PMID: 19884327). TNN is the fourth and final member of the extracellular matrix protein family of tenascins. In vitro, the presence of tenascin-W increased the proportion of elongated human umbilical vein endothelial cells (HUVECs) and augmented the mean speed of cell migration. Furthermore, tenascin-W triggered sprouting of HUVEC spheroids to a similar extent as the proangiogenic factor tenascin-C. Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro(PMID: 19884327). The predicted molecular weight of the protein is 144 kDa in human and 173 kDa in mouse.