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TORC1/CRTC1 Rekombinanter Antikörper

TORC1/CRTC1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250870G10

Kat-Nr. : 86226-3-PBS

Synonyme

CRTC1, CREB-regulated transcription coactivator 1, KIAA0616, MECT1, TORC 1

Filter:
  • Western Blot (WB) analysis of various lysates using TORC1/CRTC1 Recombinant antibody (86226-3-RR)

    WB analysis using 86226-3-RR (same clone as 86226-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86226-3-RR (TORC1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86226-3-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86226-3-RR

    Affinity and Kinetic Characterization of 86226-3-RR

    Biolayer interferometry (BLl) kinetic assays of 86226-3-RR against Human TORC1/CRTC1 were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

86226-3-PBS bindet in WB, Indirect ELISA TORC1/CRTC1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen TORC1/CRTC1 fusion protein Ag0693
Vollständiger Name CREB regulated transcription coactivator 1
Berechnetes Molekulargewicht 75 kDa
Beobachtetes Molekulargewicht 68-80 kDa
GenBank-ZugangsnummerBC028050
Gene symbol CRTC1
Gene ID (NCBI) 23373
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CRTC1, also named as MECT1,TORC1, and WAMTP1, belongs to the TORC family. It is a transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. CRTC1 acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. It enhances the interaction of CREB1 with TAF4. CRTC1 regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. It is a potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. CRTC1 is also a coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, CRTC1 involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. It may be required for dendritic growth of developing cortical neurons. CRTC1 has some isoforms produced by alternative splicing with MW of 67 kDa, 68 kDa and 62 kDa. Sometimes it appears as a 75-80 kDa band probably due to phosphorylation (PMID: 17183642; 22770221)