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TPSB2 Polyklonaler Antikörper

TPSB2 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 15332-1-PBS

Synonyme

EC:3.4.21.59, TPS2, Tryptase 2, tryptase beta 2, Tryptase beta-2

Filter:
  • Western Blot (WB) analysis of various lysates using TPSB2 Polyclonal antibody (15332-1-AP)

    WB analysis using 15332-1-AP (same clone as 15332-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 15332-1-AP (TPSB2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. TPSB2 deficient cell line K-562 served as a negative control. This data was developed using the same antibody clone with 15332-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

15332-1-PBS bindet in WB, Indirect ELISA TPSB2 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TPSB2 fusion protein Ag7335
Vollständiger Name tryptase beta 2
Berechnetes Molekulargewicht 31 kDa
Beobachtetes Molekulargewicht31 kDa
GenBank-ZugangsnummerBC065923
Gene symbol TPSB2
Gene ID (NCBI) 64499
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Tryptase beta-2 (TPSB2), also known as TPS2, is a member of the peptidase S1 family and the mast cell-specific tryptase subfamily. It is a serine protease primarily expressed in mast cells and basophils. TPSB2 is synthesized as a proenzyme, stored in secretory granules, and released upon cell activation. It plays a crucial role in allergic reactions and inflammation by cleaving extracellular matrix proteins, activating protease-activated receptors (PARs), and processing cytokines like IL-33. Elevated levels of TPSB2 are associated with conditions such as asthma, allergic rhinitis, and anaphylaxis, making it a biomarker and therapeutic target in these areas.