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TRAF4 Polyklonaler Antikörper

TRAF4 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IHC, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 10083-2-AP

Synonyme

CART1, MLN 62, MLN62, RING finger protein 83, RNF83, TRAF4

Galerie der Validierungsdaten

Geprüfte Anwendungen

Veröffentlichte Anwendungen

IHCSee 1 publications below

Produktinformation

10083-2-AP bindet in IHC, ELISA TRAF4 und zeigt Reaktivität mit human

Getestete Reaktivität human
In Publikationen genannte Reaktivitäthuman
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TRAF4 fusion protein Ag0121
Vollständiger Name TNF receptor-associated factor 4
Berechnetes Molekulargewicht 54 kDa
GenBank-ZugangsnummerBC001769
Gene symbol TRAF4
Gene ID (NCBI) 9618
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TRAF4 is the fourth member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with and mediate signal transduction from members of the TNF receptor superfamily. TRAF1 and TRAF2 are two related proteins that form a heterodimeric complex that associates with the cytoplasmic domain of the TNF-receptor type 2. The third member TRAF3 associates with the cytoplasmic domain of CD40. TRAF4 has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-KAPPA B activation. This protein also binds to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. TRAF4 thus, is thought to be involved in the oxidative activation of MAPK8/JNK.

Publikationen

SpeciesApplicationTitle
humanIHC

Cell Death Dis

Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness.

Authors - Yu-Chan Chang
View Article