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TREM2 Rekombinanter Antikörper

TREM2 Rekombinant Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

CloneNo.

240384B7

Kat-Nr. : 83438-6-PBS

Synonyme

240384B7, TREM 2, TREM-2, Trem2a, Trem2b

Filter:
  • Western Blot (WB) analysis of THP-1 cells using TREM2 Recombinant antibody (83438-6-RR)

    WB analysis of THP-1 using 83438-6-RR (same clone as 83438-6-PBS)

    PMA treated THP-1 cells were subjected to SDS PAGE followed by western blot with 83438-6-RR (TREM2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83438-6-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of THP-1 cells using TREM2 Recombinant antibody (83438-6-RR)

    WB analysis of THP-1 using 83438-6-RR (same clone as 83438-6-PBS)

    Non-treated and PMA treated THP-1 cellls were subjected to SDS PAGE followed by western blot with 83438-6-RR (TREM2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83438-6-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83438-6-RR

    Affinity and Kinetic Characterization of 83438-6-RR

    Biolayer interferometry (BLl) kinetic assays of 83438-6-RR against Human TREM2 were performed. The affinity constant is 38.7 nM.

Geprüfte Anwendungen

Produktinformation

83438-6-PBS bindet in WB, ELISA TREM2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen TREM2 fusion protein Eg0747
Vollständiger Name triggering receptor expressed on myeloid cells 2
Berechnetes Molekulargewicht 222 aa, 25 kDa
Beobachtetes Molekulargewicht26-32 kDa
GenBank-ZugangsnummerBC032362
Gene symbol TREM2
Gene ID (NCBI) 54209
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TREM2 (triggering receptor expressed on myeloid cells 2) is a cell surface receptor belongs to TREM family that is expressed on osteoclast, dendritic cells, macrophages, nature killers, neutrophils and microglia (PMID: 19302484). TREM2 is localized predominantly in the Golgi complex, but also shuttles to and from the cell surface in endocytic and exocytic vesicles (PMID: 16675145). TREM2 associates with DAP12 to initiate the intracellular signalling cascade via an immunoreceptor tyrosine-based activation motif (ITAM) domain and tyrosine-kinases (PMID: 23977213).