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TRIM52 Polyklonaler Antikörper

TRIM52 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 20948-1-PBS

Synonyme

RNF102, tripartite motif containing 52

Filter:
  • Western Blot (WB) analysis of various lysates using TRIM52 Polyclonal antibody (20948-1-AP)

    WB analysis using 20948-1-AP (same clone as 20948-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20948-1-AP (TRIM52 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20948-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human ovary cancer tissue using TRIM52 Polyclonal antibody (20948-1-AP)

    IHC staining of human ovary cancer using 20948-1-AP (same clone as 20948-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary cancer tissue slide using 20948-1-AP (TRIM52 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20948-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

20948-1-PBS bindet in WB, IHC, Indirect ELISA TRIM52 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TRIM52 fusion protein Ag15064
Vollständiger Name tripartite motif-containing 52
Berechnetes Molekulargewicht 297 aa, 35 kDa
Beobachtetes Molekulargewicht35 kDa
GenBank-ZugangsnummerBC007372
Gene symbol TRIM52
Gene ID (NCBI) 84851
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TRIM52 (Tripartite motif 52) is a member of the family of highly conserved RBCC (a RING-finger, two B-boxes, and a predicted alpha-helical Coiled-Coil domain were linked to the N-terminal region in sequence) proteins with more than 70 isoforms, which plays an important role in tumorigenesis through different signaling pathways (PMID: 35837156). TRIM52 promotes tumorigenesis in ovarian cancer by activating the nuclear factor (NF)-κB signaling pathway. Knocking-down of TRIM52 in ovarian cancer cells suppresses cell invasion, cell migration and cell proliferation, while inducing apoptosis (PMID: 30918473, 28073078).