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TRIM8 Rekombinanter Antikörper

TRIM8 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242501B6

Kat-Nr. : 85169-1-PBS

Synonyme

RING-type E3 ubiquitin transferase TRIM8, Glioblastoma-expressed RING finger protein, GERP, EC:2.3.2.27, E3 ubiquitin-protein ligase TRIM8

Filter:
  • Western Blot (WB) analysis of various lysates using TRIM8 Recombinant antibody (85169-1-RR)

    WB analysis using 85169-1-RR (same clone as 85169-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85169-1-RR (TRIM8 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85169-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85169-1-RR

    Affinity and Kinetic Characterization of 85169-1-RR

    Biolayer interferometry (BLl) kinetic assays of 85169-1-RR against Human TRIM8 were performed. The affinity constant is 0.647 nM.

Geprüfte Anwendungen

Produktinformation

85169-1-PBS bindet in WB, Indirect ELISA TRIM8 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen TRIM8 fusion protein Ag26517
Vollständiger Name tripartite motif-containing 8
Berechnetes Molekulargewicht 61 kDa
Beobachtetes Molekulargewicht61 kDa
GenBank-ZugangsnummerBC021925
Gene symbol TRIM8
Gene ID (NCBI) 81603
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TRIM8 (Tripartite motif containing protein 8), also known as RNF27 (RING finger protein 27), a member of TRIM family proteins, is known to play a dual role as both tumor suppressor and oncogene, and to function at the crosstalk of cancer and innate immunity. TRIM8 can function at two subcellular sites-nucleus and cytoplasm-to regulate NF-κB, one of the central signaling pathways that plays a critical role in carcinogenesis and inflammatory diseases (PMID: 33230447, 22262183). TRIM8 is composed of 551 amino acids (aa) with a molecular weight of 61.5 kDa, contains a Nuclear Localization Signal (NLS), and forms specific nuclear structures similar to the TRIM19/PML Nuclear Bodies (NBs) (PMID: 33807506, 29182544).