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TRMT1 Polyklonaler Antikörper

TRMT1 Polyklonal Antikörper für WB, IHC, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 14970-1-PBS

Synonyme

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  • Western Blot (WB) analysis of HeLa cells using TRMT1 Polyclonal antibody (14970-1-AP)

    WB analysis of HeLa using 14970-1-AP (same clone as 14970-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 14970-1-AP (TRMT1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14970-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human colon cancer tissue using TRMT1 Polyclonal antibody (14970-1-AP)

    IHC staining of human colon cancer using 14970-1-AP (same clone as 14970-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 14970-1-AP (TRMT1 antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 14970-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human colon cancer tissue using TRMT1 Polyclonal antibody (14970-1-AP)

    IHC staining of human colon cancer using 14970-1-AP (same clone as 14970-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 14970-1-AP (TRMT1 antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 14970-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using TRMT1 Polyclonal antibody (14970-1-AP)

    IF Staining of HeLa using 14970-1-AP (same clone as 14970-1-PBS)

    Immunofluorescent analysis of HeLa cells using 14970-1-AP (TRMT1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 14970-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

14970-1-PBS bindet in WB, IHC, IF/ICC, Indirect ELISA TRMT1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TRMT1 fusion protein Ag6837
Vollständiger Name TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae)
Berechnetes Molekulargewicht 81 kDa
Beobachtetes Molekulargewicht 72 kDa
GenBank-ZugangsnummerBC002492
Gene symbol TRMT1
Gene ID (NCBI) 55621
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TRMT1 is an RNA methyltransferase responsible for the formation of N2,N2-dimethylguanosine (m2,2G) at position 26 in both cytosolic and mitochondrial tRNAs.TRMT1-catalyzed tRNA modifications are important for maintenance of global protein translation levels including proteins involved in cellular growth, development, and stress response. Human neural stem cells with TRMT1 knockdowns were found to have hypersensitivity to redox stress, implicating TRMT1 and the m2,2G26 modification in the regulation of redox homeostasis.