TRPA1 Polyklonaler Antikörper

TRPA1 Polyklonal Antikörper für WB, IHC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Hausschwein, human, Maus, Ratte

Anwendung

WB, IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen(31)

Kat-Nr. : 19124-1-AP

Synonyme

ANKTM1, p120, Wasabi receptor



Geprüfte Anwendungen

Erfolgreiche Detektion in WBSH-SY5Y-Zellen, Hausschwein-Kolongewebe
Erfolgreiche Detektion in IHCMaus-Cerebellum-Gewebe, Maushirngewebe
Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

AnwendungVerdünnung
Western Blot (WB)WB : 1:1000-1:4000
Immunhistochemie (IHC)IHC : 1:250-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

19124-1-AP bindet in WB, IHC, IF, ELISA TRPA1 und zeigt Reaktivität mit Hausschwein, human, Maus, Ratten

Getestete Reaktivität Hausschwein, human, Maus, Ratte
In Publikationen genannte Reaktivitäthuman, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name transient receptor potential cation channel, subfamily A, member 1
Berechnetes Molekulargewicht 140 kDa
Beobachtetes Molekulargewicht 120-130 kDa
GenBank-ZugangsnummerNM_007332
Gene symbol TRPA1
Gene ID (NCBI) 8989
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS with 0.02% sodium azide and 50% glycerol
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TRPA1, also named as ANKTM1, belongs to the transient receptor family. TRPA1 is a receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. TRPA1 has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. It acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. It may be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds.

Protokolle

PRODUKTSPEZIFISCHE PROTOKOLLE
WB protocol for TRPA1 antibody 19124-1-APProtokoll herunterladen
IHC protocol for TRPA1 antibody 19124-1-APProtokoll herunterladenl
STANDARD-PROTOKOLLE
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen

Publikationen

SpeciesApplicationTitle
mouseWB,IF

Metabolism

IFT80 and TRPA1 cooperatively regulate bone formation by calcium signaling in response to mechanical stimuli

Authors - Ting Wang
ratWB

Phytomedicine

Yu-Xue-Bi capsule ameliorates aggressive synovitis and joint damage in rheumatoid arthritis via modulating the SUCNR1/HIF-1α/TRPV1 axis

Authors - Wenjia Chen
mouseIHC

J Control Release

A dual receptors-targeting and size-switchable "cluster bomb" co-loading chemotherapeutic and transient receptor potential ankyrin 1 (TRPA-1) inhibitor for treatment of triple negative breast cancer.

Authors - Yashi Wang

Front Pharmacol

The efficacy of ophiopogonanone B in treating the cough in mice infected with Mycoplasma pneumoniae

Authors - Nan-Nan Liu
rat,humanWB,IF

J Ethnopharmacol

Ligustilide covalently binds to Cys703 in the pre-S1 helix of TRPA1, blocking the opening of channel and relieving pain in rats with acute soft tissue injury

Authors - Kaixue Zhang
mouseWB,IF

Mol Nutr Food Res

Menthol from Mentha piperita Suppresses the Milk Production of Lactating Mammary Epithelial Cells In Vivo and In Vitro.

Authors - Norihiro Suzuki