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TRPC4 Polyklonaler Antikörper

TRPC4 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 21349-1-PBS

Synonyme

Trp-related protein 4, TRP4, Trp related protein 4, hTrp-4, HTRP4

Filter:
  • Western Blot (WB) analysis of various lysates using TRPC4 Polyclonal antibody (21349-1-AP)

    WB analysis using 21349-1-AP (same clone as 21349-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21349-1-AP (TRPC4 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21349-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human kidney tissue using TRPC4 Polyclonal antibody (21349-1-AP)

    IHC staining of human kidney using 21349-1-AP (same clone as 21349-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney using 21349-1-AP (TRPC4 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 21349-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human kidney tissue using TRPC4 Polyclonal antibody (21349-1-AP)

    IHC staining of human kidney using 21349-1-AP (same clone as 21349-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney using 21349-1-AP (TRPC4 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 21349-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

21349-1-PBS bindet in WB, IHC, Indirect ELISA TRPC4 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TRPC4 fusion protein Ag15698
Vollständiger Name transient receptor potential cation channel, subfamily C, member 4
Berechnetes Molekulargewicht 977 aa, 112 kDa
Beobachtetes Molekulargewicht 100-120 kDa
GenBank-ZugangsnummerBC104725
Gene symbol TRPC4
Gene ID (NCBI) 7223
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TRPC4 (Transient Receptor Potential Paradigm 4) is a non-selective calcium channel protein widely found in the nervous system and cardiovascular system. TRPC4 regulates intracellular calcium levels through the activation of signaling pathways mediated by Gq/11 and Gi/o-coupled receptors, and is involved in neurotransmission, neuronal excitability, and vascular endothelial cell function. In the nervous system, TRPC4 is associated with neuropsychiatric disorders such as depression and anxiety, and its inhibitors show antidepressant and anxiolytic potential. In the cardiovascular system, TRPC4 affects vascular permeability and diastolic function by regulating calcium ion inward flow and plays an important role in hypoxia-induced pulmonary hypertension. In addition, TRPC4 is involved in thermoregulation, sensing changes in internal temperature to regulate the drop in body temperature. aberrant expression of TRPC4 is associated with a variety of diseases, making it a potential therapeutic target!