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TRPC4 Rekombinanter Antikörper

TRPC4 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242444F8

Kat-Nr. : 85334-2-PBS

Synonyme

242444F8, hTrp 4, HTRP4, hTrp-4, Trp related protein 4

Filter:
  • Western Blot (WB) analysis of various lysates using TRPC4 Recombinant antibody (85334-2-RR)

    WB analysis using 85334-2-RR (same clone as 85334-2-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85334-2-RR (TRPC4 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85334-2-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

85334-2-PBS bindet in WB, Indirect ELISA TRPC4 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen TRPC4 fusion protein Ag15698
Vollständiger Name transient receptor potential cation channel, subfamily C, member 4
Berechnetes Molekulargewicht 977 aa, 112 kDa
Beobachtetes Molekulargewicht140 kDa
GenBank-ZugangsnummerBC104725
Gene symbol TRPC4
Gene ID (NCBI) 7223
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TRPC4 (Transient Receptor Potential Paradigm 4) is a non-selective calcium channel protein widely found in the nervous system and cardiovascular system. TRPC4 regulates intracellular calcium levels through the activation of signaling pathways mediated by Gq/11 and Gi/o-coupled receptors, and is involved in neurotransmission, neuronal excitability, and vascular endothelial cell function. In the nervous system, TRPC4 is associated with neuropsychiatric disorders such as depression and anxiety, and its inhibitors show antidepressant and anxiolytic potential. In the cardiovascular system, TRPC4 affects vascular permeability and diastolic function by regulating calcium ion inward flow and plays an important role in hypoxia-induced pulmonary hypertension. In addition, TRPC4 is involved in thermoregulation, sensing changes in internal temperature to regulate the drop in body temperature. aberrant expression of TRPC4 is associated with a variety of diseases, making it a potential therapeutic target!