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TRPM3 Polyklonaler Antikörper

TRPM3 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 12724-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using TRPM3 Polyclonal antibody (12724-1-AP)

    WB analysis using 12724-1-AP (same clone as 12724-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 12724-1-AP (TRPM3 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12724-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

12724-1-PBS bindet in WB, Indirect ELISA TRPM3 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TRPM3 fusion protein Ag3421
Vollständiger Name transient receptor potential cation channel, subfamily M, member 3
Berechnetes Molekulargewicht 1732 aa, 197 kDa
Beobachtetes Molekulargewicht160-210 kDa
GenBank-ZugangsnummerBC022454
Gene symbol TRPM3
Gene ID (NCBI) 80036
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The transient receptor potential melastatin-3 (TRPM3) channel belongs to the family of transient receptor potential (TRP) cation channels that are expressed in a variety of tissues and cell types, including kidney, brain, dorsal root ganglia, cardiomyocytes and pancreatic beta-cells. TRPM3 channels can be activated by the neurosteroid pregnenolone sulfate, and they are regulated by phosphoinositides, and perhaps by calmodulin. Stimulation of TRPM3 channels is connected with heat sensation by somatosensory neurons, insulin secretion by pancreatic beta-cells, regulation of neurotransmitter release, iris constriction, and tumor promotion. The calculated MW of TRPM3 is 197 kDa, 12724-1-AP can detect a band around 160 kDa, which likely corresponds to different splice variant. (PMID: 28720517,21198543)