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TRPM7 Polyklonaler Antikörper

TRPM7 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 55251-1-PBS

Synonyme

CHAK, CHAK1, Channel kinase 1, Channel-kinase 1, EC:2.7.11.1

Filter:
  • Western Blot (WB) analysis of various lysates using TRPM7 Polyclonal antibody (55251-1-AP)

    WB analysis using 55251-1-AP (same clone as 55251-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 55251-1-AP (TRPM7 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55251-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

55251-1-PBS bindet in WB, Indirect ELISA TRPM7 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name transient receptor potential cation channel, subfamily M, member 7
Berechnetes Molekulargewicht 213 kDa
Beobachtetes Molekulargewicht220 kDa
GenBank-ZugangsnummerNM_017672
Gene symbol TRPM7
Gene ID (NCBI) 54822
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Transient receptor potential melastatin 7 (TRPM7), along with the closely related TRPM6, are unique channels that have dual operations: cation permeability and kinase activity. In contrast to the limited tissue distribution of TRPM6, TRPM7 is widely expressed among tissues and is therefore implicated in a variety of cellular functions physiologically and pathophysiologically. The discovery of TRPM7's unique structure imparting dual ion channel and kinase activities shed light onto novel and peculiar biological functions, such as Mg2+ homeostasis, cellular Ca2+ flickering, and even intranuclear transcriptional regulation by a cleaved kinase domain translocated to nuclei. The calculated MW of TRPM7 is 213 kDa, 55251-1-AP can detect a band around 220 kDa. (PMID: 32503408)