TRPM8 Polyklonaler Antikörper

TRPM8 Polyklonal Antikörper für IHC, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IHC, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 12813-1-PBS

Synonyme

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  IHC staining of human liver cancer using 12813-1-AP (same clone as 12813-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 12813-1-AP (TRPM8 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12813-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver cancer using 12813-1-AP (same clone as 12813-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 12813-1-AP (TRPM8 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12813-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver cancer using 12813-1-AP (same clone as 12813-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 12813-1-AP (TRPM8 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12813-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver cancer using 12813-1-AP (same clone as 12813-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 12813-1-AP (TRPM8 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12813-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human prostate cancer using 12813-1-AP (same clone as 12813-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using 12813-1-AP (TRPM8 antibody) at dilution of 1:100 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12813-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human prostate cancer using 12813-1-AP (same clone as 12813-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using 12813-1-AP (TRPM8 antibody) at dilution of 1:100 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12813-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon cancer using 12813-1-AP (same clone as 12813-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 12813-1-AP (TRPM8 antibody) at dilution of 1:100 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12813-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon cancer using 12813-1-AP (same clone as 12813-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 12813-1-AP (TRPM8 antibody) at dilution of 1:100 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12813-1-PBS in a different storage buffer formulation.

• 

  IF Staining of SH-SY5Y using 12813-1-AP (same clone as 12813-1-PBS)

  Immunofluorescent analysis of SH-SY5Y cells using 12813-1-AP (TRPM8 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG. This data was developed using the same antibody clone with 12813-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

12813-1-PBS bindet in IHC, IF/ICC, Indirect ELISA TRPM8 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: TRPM8 fusion protein Ag3483
• Vollständiger Name: transient receptor potential cation channel, subfamily M, member 8
• Berechnetes Molekulargewicht: 1104 aa, 128 kDa
• GenBank-Zugangsnummer: BC001135
• Gene symbol: TRPM8
• Gene ID (NCBI): 79054
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TRPM8, also known as CMR1 (cold-menthol receptor-1), is a nonselective cation channel activated by cold and the cooling substances menthol and icilin (PMID: 11893340; 11882888). It serves as a neuronal sensor of cold temperatures. Functioning TRPM8 channels are required for behavioral responses to innocuous cool, noxious cold, injury-evoked cold hypersensitivity, and cooling-mediated analgesia (PMID: 17538622; 21438154; 16920620; 21984952). Additionally, TRPM8 has also been reported to be involved in thermoregulation and the regulation of basal tear flow (PMID: 21407809; 21076394). TRPM8 is expressed extensively in sensory nerves, human prostate and overexpressed in a variety of cancers including prostate, breast, lung, colon and skin melanomas (PMID: 11325849; 20816009).