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TRPV4 Polyklonaler Antikörper

TRPV4 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 27892-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using TRPV4 Polyclonal antibody (27892-1-AP)

    WB analysis using 27892-1-AP (same clone as 27892-1-PBS)

    SH-SY5Y cell lysates (heated at 100℃, heated at 37℃) were subjected to SDS PAGE followed by western blot with 27892-1-AP (TRPV4 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27892-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

27892-1-PBS bindet in WB, Indirect ELISA TRPV4 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TRPV4 fusion protein Ag27253
Vollständiger Name transient receptor potential cation channel, subfamily V, member 4
Berechnetes Molekulargewicht 98 kDa
Beobachtetes Molekulargewicht 85~98 kDa
GenBank-ZugangsnummerNM_001177428.1
Gene symbol TRPV4
Gene ID (NCBI) 59341
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TRPV4, also named as VRL2 and VROAC, belongs to the transient receptor family and TrpV subfamily. It is a non-selective calcium permeant cation channel protein which involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. It is activated by low pH, citrate and phorbol esters. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3), spondylometaphyseal dysplasia Kozlowski type (SMDK) and metatropic dysplasia (MTD). Multiple transcript variants encoding different isoforms have been found.