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TRPV4 Rekombinanter Antikörper

TRPV4 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241143H1

Kat-Nr. : 84091-4-PBS

Synonyme

Vanilloid receptor-like channel 2, TRP12, OTRPC4, Osm-9-like TRP channel 4, Osm 9 like TRP channel 4

Filter:
  • Western Blot (WB) analysis of various lysates using TRPV4 Recombinant antibody (84091-4-RR)

    WB analysis using 84091-4-RR (same clone as 84091-4-PBS)

    Rat brain tissue(heated at 100 ° C and unboilded)lysates were subjected to SDS PAGE followed by western blot with 84091-4-RR (TRPV4 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84091-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84091-4-RR

    Affinity and Kinetic Characterization of 84091-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84091-4-RR against Human TRPV4 were performed. The affinity constant is 2.57 nM.

Geprüfte Anwendungen

Produktinformation

84091-4-PBS bindet in WB, Indirect ELISA TRPV4 und zeigt Reaktivität mit human, Ratten

Getestete Reaktivität human, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen TRPV4 fusion protein Ag27253
Vollständiger Name transient receptor potential cation channel, subfamily V, member 4
Berechnetes Molekulargewicht 98 kDa
Beobachtetes Molekulargewicht 85~98 kDa
GenBank-ZugangsnummerNM_001177428.1
Gene symbol TRPV4
Gene ID (NCBI) 59341
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TRPV4, also called VRL2 and VROAC, belongs to the transient receptor family and TrpV subfamily. It is a non-selective calcium permeant cation channel protein which involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. It is activated by low pH, citrate and phorbol esters. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3), spondylometaphyseal dysplasia Kozlowski type (SMDK) and metatropic dysplasia (MTD). Multiple transcript variants encoding different isoforms have been found.