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TSSK6 Polyklonaler Antikörper

TSSK6 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 14081-1-PBS

Synonyme

Cancer/testis antigen 72, CT72, EC:2.7.11.1, Serine/threonine-protein kinase SSTK, Small serine/threonine kinase

Filter:
  • Western Blot (WB) analysis of various lysates using TSSK6 Polyclonal antibody (14081-1-AP)

    WB analysis using 14081-1-AP (same clone as 14081-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 14081-1-AP (TSSK6 antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14081-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

14081-1-PBS bindet in WB, Indirect ELISA TSSK6 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TSSK6 fusion protein Ag5209
Vollständiger Name testis-specific serine kinase 6
Berechnetes Molekulargewicht30.3 kDa
Beobachtetes Molekulargewicht30 kDa
GenBank-ZugangsnummerBC014611
Gene symbol TSSK6
Gene ID (NCBI) 83983
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TSSK6 (testis-specific serine kinase 6) is a testis-specific protein kinase that is highly conserved in mammals and essential for spermatogenesis. In spermatozoa, TSSK6 is expressed after meiosis and is localized to the nucleus of spermatocytes and to the posterior part of the head of spermatocytes. TSSK6-deficient spermatozoa exhibit a defective histone-to-fischerin transition (required for chromatin remodeling after meiosis), as well as a reduction in actin polymerization in spermatocytes. The result is striking morphological defects in the spermatozoa, including nuclear malformations, a hairpin shape with the head facing backward, or complete separation of the head. In addition, Tssk6 is frequently aberrantly expressed in colorectal cancer and exhibits oncogenic activity.