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TTBK2 Rekombinanter Antikörper

TTBK2 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241456B4

Kat-Nr. : 84634-1-PBS

Synonyme

241456B4, EC:2.7.11.1, KIAA0847, SCA11, tau tubulin kinase 2

Filter:
  • Western Blot (WB) analysis of various lysates using TTBK2 Recombinant antibody (84634-1-RR)

    WB analysis using 84634-1-RR (same clone as 84634-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84634-1-RR (TTBK2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84634-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HeLa cells using TTBK2 Recombinant antibody (84634-1-RR)

    WB analysis of HeLa using 84634-1-RR (same clone as 84634-1-PBS)

    WB result of TTBK2 antibody (84634-1-RR; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-TTBK2 transfected HeLa cells. This data was developed using the same antibody clone with 84634-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84634-1-RR

    Affinity and Kinetic Characterization of 84634-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84634-1-RR against Human TTBK2 were performed. The affinity constant is 0.14 nM.

Geprüfte Anwendungen

Produktinformation

84634-1-PBS bindet in WB, Indirect ELISA TTBK2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen TTBK2 fusion protein Ag7108
Vollständiger Name tau tubulin kinase 2
Berechnetes Molekulargewicht 137 kDa
Beobachtetes Molekulargewicht 137-150 kDa
GenBank-ZugangsnummerBC071556
Gene symbol TTBK2
Gene ID (NCBI) 146057
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TTBK2(tau tubulin kinase 2) plays an important role in the tau cascade and in spinocerebellar degeneration. The N-terminus of TTBK2 has a serine-threonine-tyrosine kinase domain, and a C-terminal region shows homology to TTBK1. TTBK1 and TTBK2 function as regulators of TDP-43 phosphorylation. TTBK1/2 may be attractive drug targets for therapeutic interventions in TDP-43 proteinopathies such as FTLD-TDP and ALS.(PMID:25473830).