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TTC21B Polyklonaler Antikörper

TTC21B Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 30112-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using TTC21B Polyclonal antibody (30112-1-AP)

    WB analysis using 30112-1-AP (same clone as 30112-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30112-1-AP (TTC21B antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30112-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse testis tissue using TTC21B Polyclonal antibody (30112-1-AP)

    IHC staining of mouse testis using 30112-1-AP (same clone as 30112-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 30112-1-AP (TTC21B antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30112-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

30112-1-PBS bindet in WB, IHC, Indirect ELISA TTC21B und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TTC21B fusion protein Ag32456
Vollständiger Name tetratricopeptide repeat domain 21B
Berechnetes Molekulargewicht151KD
Beobachtetes Molekulargewicht 55 kDa
GenBank-ZugangsnummerNM_024753
Gene symbol TTC21B
Gene ID (NCBI) 79809
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TTC21B, also known as THM1, IFT139, belongs to the TTC21 family, containing several tetratricopeptide repeat (TPR) domains. TTC21B is a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). TTC21B is essential for retrograde trafficking of IFT-1, IFT-B, and GPCRs (PubMed:27932497). TTC21B is localized to the cilium axoneme and may play a role in retrograde intraflagellar transport in cilia (PMID: 18327258). Mutations in TTC21B are associated with nephronophthisis 12 (NPHP12)and short-rib thoracic dysplasia 4 with or without polydactyly (SRTD4)(PMID: 21258341).