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TTDN1 Polyklonaler Antikörper

TTDN1 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 25410-1-PBS

Synonyme

C7orf11, ABHS, TTD non-photosensitive 1 protein, ORF20, MPLKIP

Filter:
  • Western Blot (WB) analysis of NIH/3T3 cells using TTDN1 Polyclonal antibody (25410-1-AP)

    WB analysis of NIH/3T3 using 25410-1-AP (same clone as 25410-1-PBS)

    NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 25410-1-AP (TTDN1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25410-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human intrahepatic cholangiocarcinoma tissue using TTDN1 Polyclonal antibody (25410-1-AP)

    IHC staining of human intrahepatic cholangiocarcinoma using 25410-1-AP (same clone as 25410-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human intrahepatic cholangiocarcinoma tissue slide using 25410-1-AP (TTDN1 antibody) at dilution of 1:100 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25410-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

25410-1-PBS bindet in WB, IHC, Indirect ELISA TTDN1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TTDN1 fusion protein Ag22094
Vollständiger Name chromosome 7 open reading frame 11
Berechnetes Molekulargewicht 179 aa, 19 kDa
Beobachtetes Molekulargewicht23 kDa
GenBank-ZugangsnummerBC026265
Gene symbol TTDN1
Gene ID (NCBI) 136647
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TTDN1 colocalizes with Plk1 at the centrosome in mitosis and the midbody during cytokinesis. It is phosphorylated by Cdk1 in mitosis, and this is required for its interaction with Plk1. Overexpression of TTDN1 or its knockdown by siRNA causes multi-polar spindles and multiple nuclei, suggesting that TTDN1 plays a role in regulating mitosis and cytokinesis. Mutations in the TTDN1 gene are associated with a distinct trichothiodystrophy phenotype. (PMID:17310276, 25290684)