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TTK Rekombinanter Antikörper

TTK Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241873B2

Kat-Nr. : 84744-1-PBS

Synonyme

241873B2, EC:2.7.12.1, ESK, hMPS1, Mps 1

Filter:
  • Western Blot (WB) analysis of various lysates using TTK Recombinant antibody (84744-1-RR)

    WB analysis using 84744-1-RR (same clone as 84744-1-PBS)

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 84744-1-RR (TTK antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84744-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HEK-293 cells using TTK Recombinant antibody (84744-1-RR)

    WB analysis of HEK-293 using 84744-1-RR (same clone as 84744-1-PBS)

    WB result of TTK antibody (84744-1-RR; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-TTK transfected HEK-293 cells. This data was developed using the same antibody clone with 84744-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

84744-1-PBS bindet in WB, Indirect ELISA TTK und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen TTK fusion protein Ag20556
Vollständiger Name TTK protein kinase
Berechnetes Molekulargewicht 97 kDa
Beobachtetes Molekulargewicht97 kDa
GenBank-ZugangsnummerBC000633
Gene symbol TTK
Gene ID (NCBI) 7272
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Mps1 family of kinases colocalizes with mitotic checkpoint proteins in kinetochores and/or spindle pole bodies/centrosomes. TTK has been shown to be a cell cycle-regulated kinase displaying maximum activity during M phase(PMID:15618221). Its kinase activity is required for proper chromosome segregation during mitosis through its involvements in microtubule-chromosome attachment error correction and the mitotic checkpoint(PMID:20937696). TTK mRNA is present at relatively high levels in testis and thymus, tissues which contain a large number of proliferating cells, but is not detected in most other benign tissues (PMID:1639825). It has 2 isoforms produced by alternative splicing (PMID:25137017).