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TXLNB Polyklonaler Antikörper

TXLNB Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 22090-1-PBS

Synonyme

MDP77, LST001, hMDP77, C6orf198, Beta-taxilin

Filter:
  • Western Blot (WB) analysis of various lysates using TXLNB Polyclonal antibody (22090-1-AP)

    WB analysis using 22090-1-AP (same clone as 22090-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 22090-1-AP (TXLNB antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22090-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

22090-1-PBS bindet in WB, Indirect ELISA TXLNB und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen TXLNB fusion protein Ag17295
Vollständiger Name taxilin beta
Berechnetes Molekulargewicht 684 aa, 77 kDa
Beobachtetes Molekulargewicht75 kDa
GenBank-ZugangsnummerBC115383
Gene symbol TXLNB
Gene ID (NCBI) 167838
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TXLNB (Taxilin beta, gliding protein beta) is a protein enriched predominantly in cardiomyocytes and belongs to the centrosome articulating protein family. It is localized in the perinuclear region of the centrosome and is closely associated with the microtubule organizing center (MTOC) and the ubiquitin-proteasome system (UPS). TXLNB plays an important role in protein homeostasis in cardiomyocytes, affecting intracellular protein degradation and quality control by regulating the interactions between centrosomes and proteasomes. TXLNB was found to have a key role in cardiomyocyte hypertrophy and cardiac proteotoxicity, and its overexpression enhances proteasome activity and reduces the accumulation of ubiquitylated proteins, whereas knockdown leads to proteasome insufficiency and a decline in cardiac function with age. In addition, TXLNB may be involved in the dynamic regulation of the cytoskeleton and microtubules.