TXNDC15 Polyklonaler Antikörper

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• KD/KO Validated

TXNDC15 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 32874-1-PBS

Synonyme

C5orf14, Thioredoxin Domain Containing 15, Thioredoxin domain-containing protein 15, UNQ335/PRO534

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  WB analysis of HeLa using 32874-1-AP (same clone as 32874-1-PBS)

  WB result of TXNDC15 antibody (32874-1-AP; 1:3000; incubated at room temperature for 1.5 hours) with sh-Control and sh-TXNDC15 transfected HeLa cells. This data was developed using the same antibody clone with 32874-1-PBS in a different storage buffer formulation.

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  WB analysis using 32874-1-AP (same clone as 32874-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32874-1-AP (TXNDC15 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32874-1-PBS in a different storage buffer formulation.

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  IHC staining of human ovary cancer using 32874-1-AP (same clone as 32874-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary cancer tissue slide using 32874-1-AP (TXNDC15 antibody) at dilution of 1:600 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 32874-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

32874-1-PBS bindet in WB, IHC, Indirect ELISA TXNDC15 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: TXNDC15 fusion protein Ag37138
• Vollständiger Name: thioredoxin domain containing 15
• Beobachtetes Molekulargewicht: 55 kDa
• GenBank-Zugangsnummer: BC032568
• Gene symbol: TXNDC15
• Gene ID (NCBI): 79770
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TXNDC15 (thioredoxin domain-containing protein 15) is a single-pass type I transmembrane protein that contains a thioredoxin domain and is primarily localized in the cytoplasm. It plays a positive regulatory role in the Hedgehog signaling pathway within cilia and actively participates in the process of ciliogenesis, exerting significant influence on the structure and function of cilia-an essential cellular organelle. Additionally, TXNDC15 has been found to form mixed disulfide complexes with endoplasmic reticulum-resident protein disulfide isomerase (PDI) family members, such as ERp57, PDI, and ERp44, suggesting its involvement in protein folding and quality control processes. Notably, mutations in the TXNDC15 gene are associated with a rare and lethal genetic disorder known as Meckel-Gruber syndrome, which is caused by defects in ciliogenesis.