TXNIP Polyklonaler Antikörper

• Featured Product
• KD/KO Validated

TXNIP Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 18243-1-PBS

Synonyme

Thioredoxin binding protein 2, thioredoxin interacting protein, Thioredoxin-binding protein 2, Thioredoxin-interacting protein, VDUP1

---

• 

  WB analysis of K-562 using 18243-1-AP (same clone as 18243-1-PBS)

  WB result of TXNIP antibody (18243-1-AP; 1:600; incubated at room temperature for 1.5 hours) with sh-Control and sh-TXNIP transfected K-562 cells. This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 18243-1-AP (same clone as 18243-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18243-1-AP (TXNIP antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human ovary tumor using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 18243-1-AP (TXNIP antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human ovary tumor using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 18243-1-AP (TXNIP antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human kidney using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 18243-1-AP (TXNIP Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human kidney using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 18243-1-AP (TXNIP Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse colon using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 18243-1-AP (TXNIP antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of rat kidney using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat kidney tissue slide using 18243-1-AP (TXNIP antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse kidney using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 18243-1-AP (TXNIP Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse kidney using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 18243-1-AP (TXNIP Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

---

Geprüfte Anwendungen

Produktinformation

18243-1-PBS bindet in WB, IHC, Indirect ELISA TXNIP und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: TXNIP fusion protein Ag13009
• Vollständiger Name: thioredoxin interacting protein
• Berechnetes Molekulargewicht: 391 aa, 44 kDa
• Beobachtetes Molekulargewicht: 44-55 kDa
• GenBank-Zugangsnummer: BC093702
• Gene symbol: TXNIP
• Gene ID (NCBI): 10628
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TXNIP, also known as VDUP-1 or TBP-2, belongs to alpha-arrestin protein family and is perhaps the only family member known to bind thioredoxin (TRX). TXNIP was induced by Vitamin D3, but not induced by another monocyte or macrophage differentiation inducer: phorbol 12-myristate 13-acetate (PMA). TXNIP bound catalytic active center of thioredoxin (TRX), which protected cells against oxidative stress. TXNIP was found to be a negative regulator of thioredoxin activity and inducer of the intracellular level of reactive oxygen species (ROS). TXNIP plays an important role in a wide variety of biological functions, such as the regulation of cell death, growth, differentiation, and energy metabolism.