Tie-2/CD202b Rekombinanter Antikörper

Tie-2/CD202b Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241753F12

Kat-Nr. : 98219-1-RR

Synonyme

HYK, Endothelial tyrosine kinase, EC:2.7.10.1, CD202b, Angiopoietin-1 receptor

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  FC experiment of bEnd.3 using 98219-1-RR

  1x10^6 bEnd.3 cells were surface stained with 0.25 ug Anti-Mouse Tie-2 Rabbit Recombinant Antibody (98219-1-RR, Clone:241753F12) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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  Affinity and Kinetic Characterization of 98219-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98219-1-RR against Mouse Tie-2/CD202b were performed. The affinity constant is below 1 pM.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: bEnd.3-Zellen

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98219-1-RR bindet in FC Tie-2/CD202b und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: endothelial-specific receptor tyrosine kinase
• Berechnetes Molekulargewicht: 126kDa
• GenBank-Zugangsnummer: NM_001290549.1
• Gene symbol: Tek
• Gene ID (NCBI): 21687
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

Tie-2, also known as CD202b or TEK, is a receptor tyrosine kinase (RTK) specifically expressed in endothelial cells. It plays a crucial role in angiogenesis, forming new blood vessels, and maintaining vascular stability. Tie-2 is a member of the Tie receptor family, characterized by the presence of immunoglobulin and epidermal growth factor (EGF) homology domains. Tie-2 plays a significant role in several vascular diseases, including vascular malformations like venous malformations. It is also implicated in pathological vascular remodeling associated with tumor growth, where it is often overexpressed in tumor vessels.