TREM-1/CD354 Rekombinanter Antikörper

TREM-1/CD354 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

240219H1

Kat-Nr. : 98022-1-PBS

Synonyme

Trem1, TREM-1, TREM 1, CD354, 240219H1

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  FC experiment of mouse splenocytes using 98022-1-RR (same clone as 98022-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse TREM-1/CD354 Rabbit Recombinant Antibody (98022-1-RR, Clone:240219H1) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Mouse Ly-6G/Ly-6C (Gr-1) (RB6-8C5) (APC-65140, Clone: RB6-8C5). Cells were not fixed. This data was developed using the same antibody clone with 98022-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98022-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98022-1-RR against Mouse CD354/TREM-1 were performed. The affinity constant is 91.8 nM.

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Geprüfte Anwendungen

Produktinformation

98022-1-PBS bindet in FC TREM-1/CD354 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: triggering receptor expressed on myeloid cells 1
• Berechnetes Molekulargewicht: 25 kDa
• GenBank-Zugangsnummer: NM_021406.5
• Gene symbol: Trem1
• Gene ID (NCBI): 58217
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

Triggering receptor expressed on myeloid cells 1 (TREM-1, also known as CD354) is a member of the immunoglobulin superfamily, which is expressed on neutrophils and monocytes. TREM1 plays a role in the innate immune system. TREM1 amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers.