UBFD1 Polyklonaler Antikörper

UBFD1 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 32161-1-AP

Synonyme

Ubiquitin-binding protein homolog, Ubiquitin Family Domain Containing 1 , Ubiquitin domain-containing protein UBFD1

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  WB analysis using 32161-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 32161-1-AP (UBFD1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: HEK-293T-Zellen, HeLa-Zellen, Jurkat-Zellen, NIH/3T3-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

32161-1-AP bindet in WB, ELISA UBFD1 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: UBFD1 fusion protein Ag36361
• Vollständiger Name: ubiquitin family domain containing 1
• Berechnetes Molekulargewicht: 309aa, 33 kDa
• Beobachtetes Molekulargewicht: 40 kDa
• GenBank-Zugangsnummer: NM_019116
• Gene symbol: UBFD1
• Gene ID (NCBI): 56061
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

UBFD1 (Ubiquitin Family Domain Containing 1) is a polyubiquitin-binding protein containing ubiquitin-like structural domains that are widely involved in protein degradation and cell signaling. This protein shows aberrant expression in a variety of cancers, especially in estrogen receptor (ER)-positive breast cancer, where high expression of UBFD1 is closely associated with poor prognosis of patients, and is considered as a potential prognostic biomarker and therapeutic target. In addition, UBFD1 was also found to be associated with MYC-mediated tumor aggressiveness in T-cell acute lymphoblastic leukemia (T-ALL), which functionally involves the endoplasmic reticulum-associated degradation (ERAD) pathway. UBFD1 is also expressed in inner ear hair cells and ear epithelial cells, suggesting that it may play a role in hearing-related diseases.