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UBFD1 Polyklonaler Antikörper

UBFD1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 32161-1-PBS

Synonyme

Ubiquitin-binding protein homolog, Ubiquitin Family Domain Containing 1 , Ubiquitin domain-containing protein UBFD1

Filter:
  • Western Blot (WB) analysis of various lysates using UBFD1 Polyclonal antibody (32161-1-AP)

    WB analysis using 32161-1-AP (same clone as 32161-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 32161-1-AP (UBFD1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32161-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

32161-1-PBS bindet in WB, Indirect ELISA UBFD1 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen UBFD1 fusion protein Ag36361
Vollständiger Name ubiquitin family domain containing 1
Berechnetes Molekulargewicht309aa, 33 kDa
Beobachtetes Molekulargewicht40 kDa
GenBank-ZugangsnummerNM_019116
Gene symbol UBFD1
Gene ID (NCBI) 56061
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

UBFD1 (Ubiquitin Family Domain Containing 1) is a polyubiquitin-binding protein containing ubiquitin-like structural domains that are widely involved in protein degradation and cell signaling. This protein shows aberrant expression in a variety of cancers, especially in estrogen receptor (ER)-positive breast cancer, where high expression of UBFD1 is closely associated with poor prognosis of patients, and is considered as a potential prognostic biomarker and therapeutic target. In addition, UBFD1 was also found to be associated with MYC-mediated tumor aggressiveness in T-cell acute lymphoblastic leukemia (T-ALL), which functionally involves the endoplasmic reticulum-associated degradation (ERAD) pathway. UBFD1 is also expressed in inner ear hair cells and ear epithelial cells, suggesting that it may play a role in hearing-related diseases.