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UFM1 Rekombinanter Antikörper

UFM1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242505E9

Kat-Nr. : 85068-5-PBS

Synonyme

Ubiquitin-fold modifier 1, ubiquitin fold modifier 1, C13orf20, BM-002, BM 002

Filter:
  • Western Blot (WB) analysis of various lysates using UFM1 Recombinant antibody (85068-5-RR)

    WB analysis using 85068-5-RR (same clone as 85068-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85068-5-RR (UFM1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85068-5-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

85068-5-PBS bindet in WB, Indirect ELISA UFM1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen UFM1 fusion protein Ag8667
Vollständiger Name ubiquitin-fold modifier 1
Berechnetes Molekulargewicht 85 aa, 9 kDa
Beobachtetes Molekulargewicht 9-12 kDa
GenBank-ZugangsnummerBC005193
Gene symbol UFM1
Gene ID (NCBI) 51569
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

UFM1 (Ubiquitin-fold modifier 1) is a ubiquitin-like protein covalently conjugated with intracellular proteins through UFMylation (modification by UFM1), a process similar to ubiquitylation (PMID: 38141606). UFM1 is conjugated to its target proteins by E1-like activating enzyme UBE1DC1 and E2-like conjugating enzyme UFC1 in a manner analogous to ubiquitylation (PMID: 28234446; 33066455). At the molecular level, UFMylation is an important mediator of the protein function. Dysregulation of the UFM1 system, e.g., the knockout of UFMylation components, disturbs proteome homeostasis and triggers endoplasmic reticulum stress. Such changes are linked to developmental disorders, tumorigenesis, tissue injury, inflammation, and several hereditary neurological syndromes (PMID: 36932998).