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UMP/CMP kinase Rekombinanter Antikörper

UMP/CMP kinase Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

251233A1

Kat-Nr. : 86475-3-PBS

Synonyme

CMPK1, CK, CMK, CMPK, Cytidine monophosphate kinase

Filter:
  • Western Blot (WB) analysis of various lysates using UMP/CMP kinase Recombinant monoclonal antibody (86475-3-RR)

    WB analysis using 86475-3-RR (same clone as 86475-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86475-3-RR (CMPK1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86475-3-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86475-3-RR

    Affinity and Kinetic Characterization of 86475-3-RR

    Biolayer interferometry (BLl) kinetic assays of 86475-3-RR against Human UMP/CMP kinase were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

86475-3-PBS bindet in WB, Indirect ELISA UMP/CMP kinase und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen UMP/CMP kinase fusion protein Ag1920
Vollständiger Name cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
Berechnetes Molekulargewicht 228 aa, 26 kDa
Beobachtetes Molekulargewicht 22 kDa
GenBank-ZugangsnummerBC014961
Gene symbol CMPK1
Gene ID (NCBI) 51727
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Pyrimidine nucleoside monophosphate kinase [UMP/CMP kinase (UMP/CMPK)] (CMPK1) is also named as CMK, CMPK, UCK, UMK, UMPK and belongs to the adenylate kinase family. It plays a crucial role in the formation of UDP, CDP, and dCDP, which are required for cellular nucleic acid synthesis(PMID:11912132). CMPK1 can use a broad spectrum of phosphate donors but the best phosphate donors are ATP and dATP. CMPK1 has been reported as a prognostic marker for non-small cell lung cancer, pancreatic cancer and breast cancer (PMID: 21642870, 22838950, 27558661). The longest deduced protein contains 228 amino acids and has a calculated molecular mass of 26 kD. However, translation likely begins at the second initiation methionine, resulting in a protein of 196 amino acids(PMID:10462544). The shorter form is the endogenously translated protein(PMID:11912132). CMPK1 has 3 isoforms with the molecular mass of 22, 16 and 26 kDa.