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UPF3B Rekombinanter Antikörper

UPF3B Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250604F11

Kat-Nr. : 86035-1-PBS

Synonyme

RENT3B, hUpf3B, hUpf3p X, hUpf3p-X, MRXS14

Filter:
  • Western Blot (WB) analysis of various lysates using UPF3B Recombinant monoclonal antibody (86035-1-RR)

    WB analysis using 86035-1-RR (same clone as 86035-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86035-1-RR (UPF3B antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86035-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86035-1-RR

    Affinity and Kinetic Characterization of 86035-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86035-1-RR against Human UPF3B were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

86035-1-PBS bindet in WB, Indirect ELISA UPF3B und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen UPF3B fusion protein Ag18568
Vollständiger Name UPF3 regulator of nonsense transcripts homolog B (yeast)
Berechnetes Molekulargewicht 483 aa, 58 kDa
Beobachtetes Molekulargewicht 58 kDa
GenBank-ZugangsnummerBC121017
Gene symbol UPF3B
Gene ID (NCBI) 65109
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Regulator of nonsense transcripts 3B (UPF3B) is also named as RENT3B, and belongs to the RENT3 family. UPF3B is a core junction protein in the Nonsense-mediated RNA decay (NMD) pathway, involved in the exonuclear transport and quality supervision of mRNA. And UPF3B showed heightened expression in hepatocellular carcinoma (HCC) tissues and was linked with adverse prognosis (PMID: 38889220). UPF3B promotes the dissociation of post-termination ribosomal complexes that lack nascent peptide. UPF3B could promote ribosome recycling, and UPF3B serves as a direct regulator of translation termination (PMID: 29333258).