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UPK3A Polyklonaler Antikörper

UPK3A Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 55229-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using UPK3A Polyclonal antibody (55229-1-AP)

    WB analysis using 55229-1-AP (same clone as 55229-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 55229-1-AP (UPK3A antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55229-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse bladder tissue using UPK3A Polyclonal antibody (55229-1-AP)

    IHC staining of mouse bladder using 55229-1-AP (same clone as 55229-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse bladder tissue slide using 55229-1-AP (Uroplakin III antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55229-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

55229-1-PBS bindet in WB, IHC, Indirect ELISA UPK3A und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name uroplakin 3A
Berechnetes Molekulargewicht 31 kDa
Beobachtetes Molekulargewicht31-33 kDa
GenBank-ZugangsnummerNM_006953
Gene symbol UPK3A
Gene ID (NCBI) 7380
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Uroplakins are a group of urothelial differentiation-related membrane proteins. They are components of the asymmetric unit membrane (AUM), which forms the apical plaques of mammalian urothelium and is believed to play a role in strengthening the urothelial apical surface thus preventing the cells from rupturing during bladder distention (PMID: 8175808). Uroplakin III (UPK3A) is a promising new urine marker for bladder cancer detection (PMID: 20346489). Loss of UPK3A expression is associated with clinicopathological features of invasive bladder cancer and poor prognosis in upper tract urothelial carcinoma (PMID: 18313120; PMID: 16686732). UPK3A has a calculated molecular weight of 30.7 kDa, with an apparent molecular weight of 47 kDa due to three potential N-glycosylation sites.