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USB1 Polyklonaler Antikörper

USB1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 21229-1-PBS

Synonyme

C16orf57, 3'-5' RNA exonuclease USB1, EC:4.6.1.-, hMpn1, hUsb1

Filter:
  • Western Blot (WB) analysis of various lysates using USB1 Polyclonal antibody (21229-1-AP)

    WB analysis using 21229-1-AP (same clone as 21229-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21229-1-AP (USB1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21229-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

21229-1-PBS bindet in WB, Indirect ELISA USB1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen USB1 fusion protein Ag15689
Vollständiger Name chromosome 16 open reading frame 57
Berechnetes Molekulargewicht 265 aa, 30 kDa
Beobachtetes Molekulargewicht31 kDa
GenBank-ZugangsnummerBC004415
Gene symbol C16orf57
Gene ID (NCBI) 79650
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

USB1 (U6 snRNA biogenesis phosphodiesterase 1) is a key nuclease primarily located within the nucleus and responsible for RNA processing. Its most well-defined function is to catalyze the hydrolysis of the 2',3'-cyclic phosphate at the 3' end of the U6 small nuclear RNA (snRNA), generating an essential 3'-hydroxyl group. This process is crucial for spliceosome assembly and pre-mRNA splicing. Mutations in the USB1 gene directly cause cartilaginous-hair hypoplasia, a rare autosomal recessive genetic disorder. Affected individuals present with short-limbed dwarfism, sparse hair, immunodeficiency, and bone marrow failure, revealing the critical roles of USB1 in skeletal development, cell cycle regulation, and immune system function. Therefore, USB1 is not only a core factor in RNA metabolism but also an important disease-associated protein.