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USP54 Polyklonaler Antikörper

USP54 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 26707-1-PBS

Synonyme

C10orf29, Inactive ubiquitin carboxyl-terminal hydrolase 54, Inactive ubiquitin-specific peptidase 54

Filter:
  • Western Blot (WB) analysis of various lysates using USP54 Polyclonal antibody (26707-1-AP)

    WB analysis using 26707-1-AP (same clone as 26707-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 26707-1-AP (USP54 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 26707-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse liver tissue using USP54 Polyclonal antibody (26707-1-AP)

    IHC staining of mouse liver using 26707-1-AP (same clone as 26707-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 26707-1-AP (USP54 antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26707-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

26707-1-PBS bindet in WB, IHC, Indirect ELISA USP54 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen USP54 fusion protein Ag25080
Vollständiger Name ubiquitin specific peptidase 54
Beobachtetes Molekulargewicht180 kDa
GenBank-ZugangsnummerBC130633
Gene symbol USP54
Gene ID (NCBI) 159195
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

USP54 is a ubiquitin-specific protease in the deubiquitinating enzyme (DUB) family that promotes the malignant progression of many cancers. As a deubiquitinating enzyme, USP54 maintains the stability of PLK4 protein through deubiquitination, which promotes centrosome amplification and GC progression. USP54 is also highly expressed in colorectal cancers, and is associated with proliferation, invasion and migration of colorectal cancer. In addition, USP54 plays a key role in the transformation of hormone-sensitive prostate cancer (HSPC) into chemoresistant prostate cancer (CRPC), and may serve as a potential therapeutic target in CRPC.