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Ubiquilin 1 Polyklonaler Antikörper

Ubiquilin 1 Polyklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 22126-1-PBS

Synonyme

UBQLN1, PLIC 1, hPLIC-1, hPLIC1, hPLIC 1

Filter:
  • Western Blot (WB) analysis of various lysates using Ubiquilin 1 Polyclonal antibody (22126-1-AP)

    WB analysis using 22126-1-AP (same clone as 22126-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 22126-1-AP (Ubiquilin 1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22126-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of Transfected HEK-293 cells using Ubiquilin 1 Polyclonal antibody (22126-1-AP)

    WB analysis of Transfected HEK-293 using 22126-1-AP (same clone as 22126-1-PBS)

    Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 22126-1-AP (Ubiquilin 1 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22126-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using Ubiquilin 1 Polyclonal antibody (22126-1-AP)

    IF Staining of HeLa using 22126-1-AP (same clone as 22126-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed HeLa cells using Ubiquilin 1 antibody (22126-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 22126-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

22126-1-PBS bindet in WB, IF/ICC, Indirect ELISA Ubiquilin 1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Ubiquilin 1 fusion protein Ag17530
Vollständiger Name ubiquilin 1
Berechnetes Molekulargewicht 589 aa, 63 kDa
Beobachtetes Molekulargewicht 63-71 kDa
GenBank-ZugangsnummerBC010066
Gene symbol Ubiquilin 1
Gene ID (NCBI) 29979
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

UBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP (PMID: 21852239). This antibody detects 70kD band of UBQLN1.