VDR Monoklonaler Antikörper

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• KD/KO Validated

VDR Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1A9C1

Kat-Nr. : 67192-1-PBS

Synonyme

NR1I1, VDR, Vitamin D3 receptor

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  WB analysis using 67192-1-Ig (same clone as 67192-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67192-1-Ig (VDR antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67192-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 67192-1-Ig (same clone as 67192-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67192-1-Ig (VDR antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67192-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HeLa using 67192-1-Ig (same clone as 67192-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 67192-1-Ig (VDR antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67192-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HeLa using 67192-1-Ig (same clone as 67192-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 67192-1-Ig (VDR antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67192-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

67192-1-PBS bindet in WB, Indirect ELISA VDR und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: VDR fusion protein Ag28188
• Vollständiger Name: vitamin D (1,25- dihydroxyvitamin D3) receptor
• Berechnetes Molekulargewicht: 48 kDa
• Beobachtetes Molekulargewicht: 48-55 kDa
• GenBank-Zugangsnummer: BC060832
• Gene symbol: VDR
• Gene ID (NCBI): 7421
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The vitamin D receptor (VDR), also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A). A disorder of vitamin D metabolism results in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. The VDR exists two isoform with the MV 48 kDa and 54 kDa.