VE-cadherin/CD144 Monoklonaler Antikörper
VE-cadherin/CD144 Monoklonal Antikörper für WB, IHC, IF-P, ELISA
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human
Anwendung
WB, IHC, IF-P, ELISA
Konjugation
Unkonjugiert
CloneNo.
4F9B10
Kat-Nr. : 66804-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
66804-1-PBS bindet in WB, IHC, IF-P, ELISA VE-cadherin/CD144 und zeigt Reaktivität mit human
Getestete Reaktivität | human |
Wirt / Isotyp | Maus / IgG1 |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | VE-cadherin/CD144 fusion protein Ag27501 |
Vollständiger Name | cadherin 5, type 2 (vascular endothelium) |
Berechnetes Molekulargewicht | 88 kDa |
Beobachtetes Molekulargewicht | 125 kDa, 100 kDa |
GenBank-Zugangsnummer | NM_001795 |
Gene symbol | VE-cadherin |
Gene ID (NCBI) | 1003 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-G-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. Vascular endothelial cadherin (VE-cadherin), also known as Cadherin-5 (CDH5) or CD144, is a member of the type II classical cadherin family of cell adhesion proteins (PMID: 21269602). VE-cadherin is expressed specifically in endothelial cells and mediates homophilic adhesion in the vascular endothelium (PMID: 1522121; 8555485; 21269602). VE-cadherin plays a role in the organization of lateral endothelial junctions and in the control of permeability properties of vascular endothelium (PMID: 1522121). VE-cadherin has also been shown to be required for angiogenesis (PMID: 16473763; 18162609).