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VEGFR2/CD309 Rekombinanter Antikörper

VEGFR2/CD309 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

240214D7

Kat-Nr. : 98027-2-PBS

Synonyme

Kdr, Krd 1, Flk1, Flk 1, 6130401C07

Filter:
  • Flow cytometry (FC) experiment of bEnd.3 cells using Anti-Mouse VEGFR2/CD309 Rabbit Recombinant Antibod (98027-2-RR)

    FC experiment of bEnd.3 using 98027-2-RR (same clone as 98027-2-PBS)

    1x10^6 bEnd.3 cells were surface stained with 0.25 ug Anti-Mouse VEGFR2/CD309 Rabbit Recombinant Antibody (98027-2-RR, Clone: 240214D7) and PE-Conjugated Goat Anti-Rabbit IgG(H+L) (red), or 0.25 ug Isotype Control (blue). Cells were not fixed. This data was developed using the same antibody clone with 98027-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98027-2-RR

    Affinity and Kinetic Characterization of 98027-2-RR

    Biolayer interferometry (BLl) kinetic assays of 83376-7-RR against Mouse VEGFR-2/Kdr were performed. The affinity constant is 1.98 nM.

Geprüfte Anwendungen

Produktinformation

98027-2-PBS bindet in FC VEGFR2/CD309 und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Fusionsprotein
Vollständiger Name kinase insert domain protein receptor
Berechnetes Molekulargewicht150KD
GenBank-ZugangsnummerNM_010612.2
Gene symbol VEGFR-2
Gene ID (NCBI) 16542
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

VEGFR2, also named as CD309, KDR and FLK1, is a receptor for VEGF or VEGFC. VEGFR2 which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. VEGFR2 functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.