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VEGFR1/Flt-1 Rekombinanter Antikörper

VEGFR1/Flt-1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242311A4

Kat-Nr. : 85761-4-PBS

Synonyme

Flt1, FLT-1, VEGFR-1, VGFR1

Filter:
  • Western Blot (WB) analysis of various lysates using VEGFR1/Flt-1 Recombinant monoclonal antibody (85761-4-RR)

    WB analysis using 85761-4-RR (same clone as 85761-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85761-4-RR (VEGFR1/Flt-1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85761-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85761-4-RR

    Affinity and Kinetic Characterization of 85761-4-RR

    Biolayer interferometry (BLl) kinetic assays of 85761-4-RR against Rat VEGFR1/Flt-1 were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

85761-4-PBS bindet in WB, Indirect ELISA VEGFR1/Flt-1 und zeigt Reaktivität mit Maus, Ratten

Getestete Reaktivität Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen VEGFR1/Flt-1 fusion protein Eg1167
Vollständiger Name fms-related tyrosine kinase 1
Beobachtetes Molekulargewicht 150-210 kDa
Gene symbol Flt1
Gene ID (NCBI) 54251
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Vascular endothelial growth factor receptor-1 (VEGFR-1, FLT-1) is a receptor tyrosine kinase belonging to the VEGFR family. VEGF is a key regulator of physiological angiogenesis and has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders, and other conditions. The biological effects of VEGF are mediated by VEGFR-1 and VEGFR-2. Both the two receptors have seven immunoglobulin-like repeats in the extracellular domain, a single transmembrane region and a tyrosine kinase domain. VEGFR-1 binds VEGFA, PIGF, and VEGFB, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Two isoforms of VEGFR-1 exist, a full-length transmembrane form and a short soluble form (sVEGFR-1) consisting of only the extracellular ligand-binding domain. (PMID: 12778165; 17109193; 8806634)