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VEGFR2/KDR Monoklonaler Antikörper

VEGFR2/KDR Monoklonal Antikörper für WB, ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

CloneNo.

1G2A8

Kat-Nr. : 67407-1-PBS

Synonyme

KDR, VEGFR2, Protein-tyrosine kinase receptor flk-1, FLK-1, EC:2.7.10.1

Filter:
  • Western Blot (WB) analysis of human placenta tissue using VEGFR2/KDR Monoclonal antibody (67407-1-Ig)

    WB analysis of human placenta using 67407-1-Ig (same clone as 67407-1-PBS)

    human placenta tissue were subjected to SDS PAGE followed by western blot with 67407-1-Ig (VEGFR2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67407-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

67407-1-PBS bindet in WB, ELISA VEGFR2/KDR und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen VEGFR2/KDR fusion protein Ag24589
Vollständiger Name kinase insert domain receptor (a type III receptor tyrosine kinase)
Berechnetes Molekulargewicht 1356 aa, 152 kDa
Beobachtetes Molekulargewicht 230 kDa
GenBank-ZugangsnummerBC131822
Gene symbol KDR
Gene ID (NCBI) 3791
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.