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Vimentin Rekombinanter Antikörper
Vimentin Rekombinant Antikörper für WB, IHC, IHC-Autostainer, IF/ICC, IF-Fro, Indirect ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human, Maus, Ratte
Anwendung
WB, IHC, IHC-Autostainer, IF/ICC, IF-Fro, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
6K21
Kat-Nr. : 80232-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
80232-1-PBS bindet in WB, IHC, IHC-Autostainer, IF/ICC, IF-Fro, Indirect ELISA Vimentin und zeigt Reaktivität mit human, Maus, Ratten
| Getestete Reaktivität | human, Maus, Ratte |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Rekombinant |
| Typ | Antikörper |
| Immunogen | Vimentin fusion protein Ag0489 |
| Vollständiger Name | vimentin |
| Berechnetes Molekulargewicht | 466 aa, 54 kDa |
| Beobachtetes Molekulargewicht | 50-55 kDa |
| GenBank-Zugangsnummer | BC000163 |
| Gene symbol | VIM |
| Gene ID (NCBI) | 7431 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Protein-A-Reinigung |
| Lagerungspuffer | PBS only |
| Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Vimentin, also named as VIM, belongs to the intermediate filament family. Vimentin is class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is important for stabilizing the architecture of the cytoplasm. Monocyte-derived macrophages secrete vimentin into the extracellular space in vitro. Secretion of vimentin was enhanced by the proinflammatory cytokine tumor necrosis factor-alpha (TNFA; 191160) and inhibited by the antiinflammatory cytokine IL10 (124092), suggesting that vimentin is involved in the immune response. Vimentin has specialized functions that contribute to specific dynamic cellular processes. As a phosphoprotein, 55-60 kDa of vimentin proteins can be observed due to the different phosphorylation level. Isoforms of vimentin (49 kDa and 60 kDa) had also been reported. (PMID: 8640945, 22728585).



























