WEE1 Polyklonaler Antikörper

WEE1 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Publikationen(9)

Kat-Nr. : 14375-1-AP

Synonyme

WEE1, WEE1 homolog (S. pombe), Wee1 like protein kinase, WEE1A, Wee1A kinase, WEE1hu



Geprüfte Anwendungen

Veröffentlichte Anwendungen

KD/KOSee 1 publications below
WBSee 7 publications below

Produktinformation

14375-1-AP bindet in WB, ELISA WEE1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
In Publikationen genannte Reaktivitäthuman, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen WEE1 fusion protein Ag5751
Vollständiger Name WEE1 homolog (S. pombe)
Berechnetes Molekulargewicht 72 kDa
Beobachtetes Molekulargewicht 72 kDa
GenBank-ZugangsnummerBC051831
Gene symbol WEE1
Gene ID (NCBI) 7465
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS with 0.02% sodium azide and 50% glycerol
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

WEE1 kinase is a serine-threonine kinase that regulates G2/M checkpoint transition. WEE1 triggers G2/M arrest through inhibitory phosphorylation on Tyr15 of CDK1 (Cdc2) and preventing entry into mitosis to allow DNA repair during DNA damage (PMID: 27427153).The predicted native molecular weight for Wee1 based on the intact human Wee1 cDNA sequence is 72 kDa, whereas the 95-110 kDa protein is a highly modified product (PMID: 7568188). Others have shown that Wee1 is 70-72 kDa and 49-55 kDa (PMID: 12214061).

Publikationen

SpeciesApplicationTitle
humanWB

J Exp Med

WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.

Authors - Ensong Guo
  • KD Validated
Human

Mol Ther

Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes.

Authors - Junyi Hu

Oncogene

miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells.

Authors - X-H He
mouseWB

Exp Cell Res

Cdc14a has a role in spermatogenesis, sperm maturation and male fertility.

Authors - Zongzhuang Wen
humanWB

Exp Cell Res

NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation.

Authors - Xin Zhao
humanWB

Exp Cell Res

The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation.

Authors - Pan Wei