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WRAP53 Rekombinanter Antikörper

WRAP53 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

251391B8

Kat-Nr. : 86487-1-PBS

Synonyme

WDR79, TCAB1, WD repeat-containing protein 79, WD40 repeat-containing protein antisense to TP53 gene, WRAP53beta

Filter:
  • Western Blot (WB) analysis of various lysates using WRAP53 Recombinant antibody (86487-1-RR)

    WB analysis using 86487-1-RR (same clone as 86487-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86487-1-RR (WRAP53 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86487-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86487-1-RR

    Affinity and Kinetic Characterization of 86487-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86487-1-RR against Human WRAP53 were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

86487-1-PBS bindet in WB, Indirect ELISA WRAP53 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen WRAP53 fusion protein Ag6522
Vollständiger Name WD repeat containing, antisense to TP53
Berechnetes Molekulargewicht 59 kDa
Beobachtetes Molekulargewicht 72-75 kDa
GenBank-ZugangsnummerBC002336
Gene symbol WRAP53
Gene ID (NCBI) 55135
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

WRAP53 (WD40-encoding RNA Antisense to p53), also known as TCAB1 and WDR79, is a multifunctional protein encoded by a gene that produces both a coding mRNA and a regulatory antisense RNA targeting the tumor suppressor p53. Initially identified for its role in maintaining genomic stability by regulating p53 expression, WRAP53 is crucial for telomerase assembly and localization to Cajal bodies, impacting telomere maintenance. It also participates in DNA damage repair and cellular stress responses. The calculated molecular weight of WRAP53 is about 59 kDa, but the actual observed molecular weight is about 72-75 kDa, which may be due to modification.