XPC Polyklonaler Antikörper

XPC Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 33279-1-AP

Synonyme

DNA repair protein complementing XP-C cells, p125, Xeroderma pigmentosum group C-complementing protein, XPCC

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  WB analysis using 33279-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 33279-1-AP (XPC antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: HEK-293-Zellen, HeLa-Zellen, K-562-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

33279-1-AP bindet in WB, ELISA XPC und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: XPC fusion protein Ag38513
• Vollständiger Name: xeroderma pigmentosum, complementation group C
• Berechnetes Molekulargewicht: 106kDa，940aa
• Beobachtetes Molekulargewicht: 106-120 kDa
• GenBank-Zugangsnummer: NM_004628.4
• Gene symbol: XPC
• Gene ID (NCBI): 7508
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

XPC (DNA repair protein complementing XP-C cells) protein is a pivotal DNA damage recognition factor that plays an indispensable role in the global-genome nucleotide excision repair (GG-NER) pathway. As the primary initiator of GG-NER, it acts as a universal sensor for a wide array of helix-distorting DNA lesions, including those induced by ultraviolet (UV) radiation and chemical carcinogens. Upon binding to damaged DNA, the XPC complex orchestrates the recruitment of the entire repair machinery, serving as a critical guardian of genomic integrity. The calculated molecular weight of XPC is about 106 kDa, but due to post-translational modifications, about 120 kDa will be observed.