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XPC Polyklonaler Antikörper

XPC Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 33279-1-PBS

Synonyme

DNA repair protein complementing XP-C cells, p125, Xeroderma pigmentosum group C-complementing protein, XPCC

Filter:
  • Western Blot (WB) analysis of various lysates using XPC Polyclonal antibody (33279-1-AP)

    WB analysis using 33279-1-AP (same clone as 33279-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33279-1-AP (XPC antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33279-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

33279-1-PBS bindet in WB, Indirect ELISA XPC und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen XPC fusion protein Ag38513
Vollständiger Name xeroderma pigmentosum, complementation group C
Berechnetes Molekulargewicht106kDa，940aa
Beobachtetes Molekulargewicht106-120 kDa
GenBank-ZugangsnummerNM_004628.4
Gene symbol XPC
Gene ID (NCBI) 7508
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

XPC (DNA repair protein complementing XP-C cells) protein is a pivotal DNA damage recognition factor that plays an indispensable role in the global-genome nucleotide excision repair (GG-NER) pathway. As the primary initiator of GG-NER, it acts as a universal sensor for a wide array of helix-distorting DNA lesions, including those induced by ultraviolet (UV) radiation and chemical carcinogens. Upon binding to damaged DNA, the XPC complex orchestrates the recruitment of the entire repair machinery, serving as a critical guardian of genomic integrity. The calculated molecular weight of XPC is about 106 kDa, but due to post-translational modifications, about 120 kDa will be observed.