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CRM1 Polyklonaler Antikörper

CRM1 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB,ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 12915-1-AP

Synonyme

CRM1, Exp1, Exportin 1, XPO1

Galerie der Validierungsdaten

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  • Western Blot (WB) analysis of HT-1080 cells using CRM1 Polyclonal antibody (12915-1-AP)

    WB analysis of HT-1080 using 12915-1-AP

    HT-1080 cells were subjected to SDS PAGE followed by western blot with 12915-1-AP (CRM1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  • Immunohistochemistry (IHC) staining of human kidney tissue using CRM1 Polyclonal antibody (12915-1-AP)

    IHC staining of human kidney using 12915-1-AP

    Immunohistochemical analysis of paraffin-embedded human kidney using 12915-1-AP (CRM1 antibody) at dilution of 1:50 (under 10x lens).

  • Immunohistochemistry (IHC) staining of human kidney tissue using CRM1 Polyclonal antibody (12915-1-AP)

    IHC staining of human kidney using 12915-1-AP

    Immunohistochemical analysis of paraffin-embedded human kidney using 12915-1-AP (CRM1 antibody) at dilution of 1:50 (under 40x lens).

Geprüfte Anwendungen

Empfohlene Verdünnung

AnwendungVerdünnung
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

WBSee 1 publications below

Produktinformation

12915-1-AP bindet in WB,ELISA CRM1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
In Publikationen genannte Reaktivitäthuman
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen CRM1 fusion protein Ag3488
Vollständiger Name exportin 1 (CRM1 homolog, yeast)
Berechnetes Molekulargewicht 1071 aa, 123 kDa
Beobachtetes Molekulargewicht 100-110 kDa
GenBank-ZugangsnummerBC032847
Gene symbol XPO1
Gene ID (NCBI) 7514
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CRM1 (chromosome region maintenance 1, also known as exportin-1 or XPO1), a member of the karyopherin β family of transport receptors, is an important nuclear export receptor recognizing proteins bearing a leucine-rich nuclear export signal (PMID: 9323133). CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs (PMID: 17317185). In addition to nuclear export, CRM1 also plays a role in centrosome duplication and spindle assembly (PMID: 22773955). Elevated CRM1 expression has been reported in several cancers, which implicates CRM1 as a potential anti-cancer drug target (PMID: 22677130; 21683812 ).

Publikationen

SpeciesApplicationTitle
humanWB

Toxicology

Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.

Authors - Chuanyang Su
View Article