CRM1 Polyklonaler Antikörper

CRM1 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Publikationen(1)

Kat-Nr. : 12915-1-AP

Synonyme

CRM1, Exp1, Exportin 1, XPO1

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• 

  WB analysis of HT-1080 using 12915-1-AP

  HT-1080 cells were subjected to SDS PAGE followed by western blot with 12915-1-AP (CRM1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

• 

  IHC staining of human kidney using 12915-1-AP

  Immunohistochemical analysis of paraffin-embedded human kidney using 12915-1-AP (CRM1 antibody) at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human kidney using 12915-1-AP

  Immunohistochemical analysis of paraffin-embedded human kidney using 12915-1-AP (CRM1 antibody) at dilution of 1:50 (under 40x lens).

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Geprüfte Anwendungen

Veröffentlichte Anwendungen

• WB: See 1 publications below

Produktinformation

12915-1-AP bindet in WB, ELISA CRM1 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CRM1 fusion protein Ag3488
• Vollständiger Name: exportin 1 (CRM1 homolog, yeast)
• Berechnetes Molekulargewicht: 1071 aa, 123 kDa
• Beobachtetes Molekulargewicht: 100-110 kDa
• GenBank-Zugangsnummer: BC032847
• Gene symbol: CRM1
• Gene ID (NCBI): 7514
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CRM1 (chromosome region maintenance 1, also known as exportin-1 or XPO1), a member of the karyopherin β family of transport receptors, is an important nuclear export receptor recognizing proteins bearing a leucine-rich nuclear export signal (PMID: 9323133). CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs (PMID: 17317185). In addition to nuclear export, CRM1 also plays a role in centrosome duplication and spindle assembly (PMID: 22773955). Elevated CRM1 expression has been reported in several cancers, which implicates CRM1 as a potential anti-cancer drug target (PMID: 22677130; 21683812 ).

Publikationen

Species	Application	Title
human	WB	Toxicology; Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.; Authors - Chuanyang Su