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XPOT Polyklonaler Antikörper

XPOT Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 12577-1-PBS

Synonyme

Exportin T, Exportin(tRNA), Exportin-T, tRNA exportin, XPO3

Filter:
  • Western Blot (WB) analysis of various lysates using XPOT Polyclonal antibody (12577-1-AP)

    WB analysis using 12577-1-AP (same clone as 12577-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 12577-1-AP (XPOT antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12577-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

12577-1-PBS bindet in WB, Indirect ELISA XPOT und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen XPOT fusion protein Ag3256
Vollständiger Name exportin, tRNA (nuclear export receptor for tRNAs)
Berechnetes Molekulargewicht 962 aa, 110 kDa
Beobachtetes Molekulargewicht100-110 kDa
GenBank-ZugangsnummerBC020569
Gene symbol XPOT
Gene ID (NCBI) 11260
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

XPOT (also known as Exportin-T) is a key member of the karyopherin-β family of nuclear transport receptors, specifically responsible for the export of a critical class of small non-coding RNAs, transfer RNAs (tRNAs), from the nucleus to the cytoplasm. This process is essential for protein synthesis, as tRNAs must function in the cytoplasm to decode mRNA sequences and deliver amino acids to the growing polypeptide chain. XPOT recognizes mature tRNAs that have been properly processed and aminoacylated in the nucleus, loading them in a RanGTP-dependent manner. Upon translocation through the nuclear pore complex, the hydrolysis of RanGTP to RanGDP in the cytoplasm triggers the release of the tRNA cargo, thereby ensuring that only functional tRNAs are utilized for translation and maintaining the spatial separation of nuclear and cytoplasmic processes.