YEATS2 Polyklonaler Antikörper

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• KD/KO Validated

YEATS2 Polyklonal Antikörper für WB, IP, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human und mehr (1)

Anwendung

WB, IHC, IP, ChIP, ELISA

Konjugation

Unkonjugiert

Publikationen(10)

Kat-Nr. : 24717-1-AP

Synonyme

KIAA1197, YEATS domain containing 2, YEATS domain-containing protein 2

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  WB analysis of HEK-293 using 24717-1-AP

  WB result of YEATS2 antibody (24717-1-AP; 1:3000; incubated at room temperature for 1.5 hours) with sh-Control and sh-YEATS2 transfected HEK-293 cells.

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  WB analysis of Jurkat using 24717-1-AP

  Jurkat cells were subjected to SDS PAGE followed by western blot with 24717-1-AP (YEATS2 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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  IP experiment of Jurkat using 24717-1-AP

  IP result of anti-YEATS2 (IP:24717-1-AP, 5ug; Detection:24717-1-AP 1:300) with Jurkat cells lysate 2000ug.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: Jurkat-Zellen
• Erfolgreiche IP: Jurkat-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:200-1:1000
• Immunpräzipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 3 publications below
• WB: See 9 publications below
• IHC: See 4 publications below
• IP: See 2 publications below
• ChIP: See 1 publications below

Produktinformation

24717-1-AP bindet in WB, IHC, IP, ChIP, ELISA YEATS2 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: YEATS2 fusion protein Ag20134
• Vollständiger Name: YEATS domain containing 2
• Berechnetes Molekulargewicht: 1422 aa, 151 kDa
• Beobachtetes Molekulargewicht: 151 kDa
• GenBank-Zugangsnummer: BC150273
• Gene symbol: YEATS2
• Gene ID (NCBI): 55689
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

YEATS domain containing 2 (YEATS2) protein is a scaffolding subunit of the ATAC complex. Studies have shown that YEATS2 is a selective histone crotonylation reader and is related to histone acetylation. In addition, YEATS2 is associated with the progression of various tumors. Overexpression of YEATS2 promotes the proliferation and migration of pancreatic cancer cells. YEATS2 has been reported to be associated with the progression of non-small-cell lung cancer through histone acetylation.

Publikationen

Species	Application	Title
human	WB	Nat Commun; YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.; Authors - Wenyi Mi ; KD Validated
human	WB,IP,IHC	Cell Biol Toxicol; YEATS2 regulates the activation of TAK1/NF-κB pathway and is critical for pancreatic ductal adenocarcinoma cell survival.; Authors - Hao Sheng ; KD Validated
human	WB,IHC	J Cell Physiol; YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration.; Authors - Zhirui Zeng ; KD Validated
human	WB	Signal Transduct Target Ther; Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma.; Authors - Yiyi Xi
mouse	WB,IHC	Phytomedicine; Cinobufacini retards progression of pancreatic ductal adenocarcinoma through targeting YEATS2/TAK1/NF-κB axis; Authors - Tian Lan
human	WB	Cancers (Basel); Overexpression of YEATS2 Remodels the Extracellular Matrix to Promote Hepatocellular Carcinoma Progression via the PI3K/AKT Pathway; Authors - Xin Liu